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Peb MOTS-c yog ib qho peptide uas tsim los ntawm cov tshuaj, muaj cov khoom zoo sib xws rau tib neeg lub cev (amino acid sequence: MRWQEMGYIFYPRKLR). Nws yog tsim nyob rau hauv cov chaw kuaj mob kom ntseeg tau tias muaj cov khoom zoo tshaj plaws thiab muaj kev ua haujlwm ntawm lub cev rau kev tshawb fawb. Ua ib lub cim mitochondrial tshiab, MOTS-c yog ib qho cuab yeej tshiab hauv kev tshawb fawb biochemistry thiab molecular biology, feem ntau yog siv los tshawb nrhiav kev tswj hwm metabolic, insulin rhiab heev, kev ua si mimetics, thiab cov txheej txheem molecular ntawm kev laus. Nws qhov tshwj xeeb siab ua rau nws muaj txiaj ntsig zoo rau kev txhim kho kev tshawb fawb hauv kev noj qab haus huv metabolic thiab kev tshawb fawb txog kev ua neej ntev.
Kev piav qhia txog khoom
Peb MOTS-c yog ib qho peptide uas tsim los ntawm cov tshuaj, muaj cov khoom zoo sib xws rau tib neeg lub cev (amino acid sequence: MRWQEMGYIFYPRKLR). Nws yog tsim nyob rau hauv cov chaw kuaj mob kom ntseeg tau tias muaj cov khoom zoo tshaj plaws thiab muaj kev ua haujlwm ntawm lub cev rau kev tshawb fawb. Ua ib lub cim mitochondrial tshiab, MOTS-c yog ib qho cuab yeej tshiab hauv kev tshawb fawb biochemistry thiab molecular biology, feem ntau yog siv los tshawb nrhiav kev tswj hwm metabolic, insulin rhiab heev, kev ua si mimetics, thiab cov txheej txheem molecular ntawm kev laus. Nws qhov tshwj xeeb siab ua rau nws muaj txiaj ntsig zoo rau kev txhim kho kev tshawb fawb hauv kev noj qab haus huv metabolic thiab kev tshawb fawb txog kev ua neej ntev.
Cov cwj pwm
| Lub Npe Lus Askiv | MOTS-c (Mitochondrial Derived Peptide) | Qhov Ceev | / |
| CAS TSIS MUAJ | 1627580-42-9 | Cov Ntawv Qhia Txog Kev Hloov Pauv | / |
| Cov Qauv Molecular | C₉₆H₁₄₇N₃₁O₂₆ | Kev Khaws Cia | 20°C los yog qis dua, qhuav |
| Mol. wt. | 2176.4 g/mol | Kev yaj tau | Yaj hauv dej, PBS buffer |
| EINECS No. | / | Daim Ntawv | Hmoov Lyophilized |
| MDL No. | MFCD32614451 | Xim | Dawb rau cov hmoov dawb dawb |
| Cov Ntsiab Lus Yaj | / | Tus nqi PH | / |
| Kev Ruaj Ntseg | Ruaj khov thaum khaws cia rau hauv lyophilized ntawm -20 ° C lossis qis dua. Tsis txhob rov ua dua qhov kev ua kom khov-thaw. Cov kua uas tau sib tov lawm yuav tsum tau muab faib ua feem thiab khaws cia rau hauv -20 ° C lossis -80 ° C rau kev siv luv luv. | ||
Cov Khoom Noj Muaj Quav
Ua ib qho peptide tsim uas huv si heev, nws cov khoom sib xyaw tsuas yog txhais los ntawm nws cov amino acid sib lawv liag. Nws tsis muaj rog, carbohydrates, lossis lwm yam macro-nutrients. Cov khoom no tsuas yog rau kev tshawb fawb siv xwb.
MOTS-c tau pom tias ua rau cov cell nqus tau qabzib ntau dua thiab ua rau cov insulin rhiab heev, tshwj xeeb tshaj yog cov leeg nqaij. Nws pab kho cov metabolism kom rov qab zoo li qub thiab tej zaum yuav tiv thaiv kev rog dhau los ntawm kev noj zaub mov thiab kev tsis kam insulin hauv cov qauv preclinical.
Nws ua kom cov kab mob tiv thaiv cellular, suav nrog txoj kev AICAR / AMPK, txhim kho lub cev lub zog rau kev ntxhov siab metabolic thiab muaj peev xwm ua raws li qee qhov txiaj ntsig ntawm kev tawm dag zog thiab kev txwv calorie.
Kev tshawb fawb qhia tias MOTS-c pab tswj cov leeg nqaij kom muaj zog thiab ruaj khov thaum lub sijhawm laus. Nws ntseeg tau tias yuav tiv thaiv cov leeg nqaij pob txha uas cuam tshuam nrog kev laus thiab txhawb nqa kev ua haujlwm ntawm lub cev los ntawm kev ua kom zoo dua ntawm kev ua haujlwm ntawm mitochondrial thiab txo kev ntxhov siab oxidative.
Ib qho cuab yeej tseem ceeb rau kev tshawb fawb hauv vitro thiab hauv vivo tshawb nrhiav lub luag haujlwm ntawm kev sib txuas lus mitochondrial-nuclear hauv kev ua haujlwm ntawm lub cev, kev rog dhau, ntshav qab zib hom 2, thiab biology ntawm kev laus.
Siv rau hauv kev tshawb fawb ua ntej kev kho mob los kawm txog cov teebmeem "kev ua si mimetic", tshuaj xyuas seb MOTS-c cuam tshuam li cas rau kev siv zog, kev siv rog, thiab kev ua siab ntev yam tsis muaj kev ua si.
Vim nws muaj cov yam ntxwv zoo rau kev ua kom lub cev zom zaub mov thiab tiv thaiv kev laus, nws yog ib qho khoom sib xyaw uas muaj kev txaus siab rau kev tshawb fawb thiab kev tsim cov tshuaj ntxiv rau tiam tom ntej rau kev noj qab haus huv ntawm lub cev zom zaub mov thiab cov khoom xyaw nquag rau kev saib xyuas tawv nqaij uas tsom mus rau kev txhawb nqa lub zog ntawm lub cev thiab kev ua kom lub cev muaj zog. (Ceeb Toom: Cov ntawv thov no feem ntau yog nyob rau theem tshawb fawb.)
Txog Peb
